In this paper, we introduce a new class of Laguerre Poly-Euler and Laguerre multi Poly-Euler polynomials. The concept of Poly-Euler number $E^{(k)}_n(a,b)$, generalized Poly-Euler polynomials $E^{(k)}_n(x;a,b,e)$ of Jolany et al., Hermite-Bernoulli polynomials $HB_n(x,y)$ of Dattoli et al., $HB^{(\alpha)}_n(x,y)$ of Pathan and Khan and Hermite based Poly-Euler polynomials $HE^{(k)}_n(x,y;a,b,e)$ of Khan are generalized to the one $LE^{(k)}_n(x,y,z;a,b,e)$. Some implicit summation formulae and general symmetry identities arising from different analytical means and applying generating functions.