The aim of this study was to prepare transfersomal formulations as transdermal deliveries for drugs of bad solubility. Transfersomes (TRSs) were chosen and prepared containing sulfur and salicylic acid by thin film hydration method. Moreover, the size, zeta potential and morphology were investigated. The formulated TRSs showed a good, small and uniform particle size of 210±0.5, 212±0.5 and 230±0.5nm for plain TRSs, sulfur TRSs and salicylic acid TRSs; respectively. The TRSs had highly negative zeta potentials of -41±0.5mV, -24±0.4mV and -72±0.5mV for plain TRSs, TRSs loaded with sulfur, and TRSs loaded with salicylic acid; respectively. The prepared TRSs were formulated into gel which can be used as topical preparation with an enhanced permeation and penetration compared with conventional gels.