This paper concerns the problem of determining or estimating the maximal upper density of the sets of nonnegative integers S whose elements do not differ by an element of a given set M of positive integers. We find some exact values and some bounds for the maximal density when the elements of M are generalized Fibonacci numbers of odd order. The generalized Fibonacci sequence of order r is a generalization of the well known Fibonacci sequence, where instead of starting with two predetermined terms, we start with r predetermined terms and each term afterwards is the sum of r preceding terms. We also derive some new properties of the generalized Fibonacci sequence of order r. Furthermore, we discuss some related coloring parameters of distance graphs generated by the set M.