With the advent of next generation sequencing (NGS) technology, shifting the paradigm of genomics from single gene to whole genomic landscape, has brought us one step closer to implementation of predictive and individualized medicine. Disease diagnosis, ri sk stratification, clonal evolution and therapeutic intervention have been proved with application of clinical whole exome sequencing that leads several clinical genomic laboratories start to offer clinical whole exome sequencing with low cost. In this review ,we explore the current state of next generation sequencing that is being used in exome sequencing to study breast cancer to improve women health.