Background and Aim: Esophageal diseases are important medical concerns in developed and developing countries, where neoplasms and esophageal varices are common, respectively. The ability to observe the intra-abdominal portion of the esophagus with two dimensional Ultrasonography has been recognized. Given the cost and invasive nature of endoscopic screening, there is an interest in the development of non-invasive predictor s for the presence and development of such esophageal diseases. Patients and Methods: The intra -abdominal portion of the esophagus was examined using 2D US for (200) patients, divided into a hepatic group; (100) patients, and a non -hepatic group; another (100) patients, presented with manifestations of liver diseases and gastrointestinal symptoms, respectively. Correlat ion between intra -abdominal esophageal wall thicknesses observed using standard 2D ultrasound and esophageal diseases detected by EGD was applied. (100) normal individuals taken as a control group. Results: The mean thicknesses of the esophageal walls were (3.7 ± 0.5) mm, in normal individuals, however Esophageal wall thicknesses ≥ 4.3 mm should correlated with esophageal diseases, confirmed by EGD. The overall accuracy of 2D ultrasound was 88.9 %. Conclusion: There is evident direct correlation between intra-abdominal esophageal wall thicknesses observed using 2D Ultrasound and esophageal diseases seen by EGD. Two-dimensional ultrasound can play an important role in screening esophageal diseases.