Cancer microenvironment appears to include a lot of factors leading to tumor growth and angiogenesis. Understanding such factors and how they participate in the signaling pathways inside the cancer microenvironment guide to the best targeting strategy for the cancer treatment. This work focuses on three of these factors, which are: Platelets Derived Growth Factor (PDGF), Hepatocyte Growth Factor (HGF) and Matrix Metalloproteinase-9 (MMP-9). It emphasizes the role of each in cancer progression and metastasis, and elucidates the extent to which these factors can be used as drug targets or inhibited for stopping the spread of cancer.