Helicobacter pylori (H. pylori) is a Gram negative spiral bacterium which colonizes gastric mucosa of nearly half of human populationwas described by Marshall and Warren in 1984 . A characteristic feature of H. Pylori infection is an excessive inflammatory response. The majority of H. pylori infections remain asymptomatic. However, still it leads to the development of histological gastritis with the recruitment of immune cells. About 10% of infected subjects develop symptomatic gastritis, erosions or peptic ulcer. Gastric cancer is the most severe consequence of H. pylori infection. Recently, a possible association between chronic infections with H. pylori and extragastric disorders - including coronary heart disease, has been intensively investigated. Here we will shed light on a possible association between chronic H.Pylori infection and one of the commonest Heart disease; Acute Coronary Syndrome (ACS).