In the information age, the rapid development of technology and information technology has created a good learning environment for each student, so that everyone can grow actively and vividly, which is the main theme of today’s information age. This paper aimed to explore the application research of intelligent multi-sensor technology in higher education teaching system. In this paper, a multi-sensor information fusion algorithm was proposed, and the application effect of higher education teaching system based on intelligent multi-sensor technology was studied and analyzed. The experimental results in this paper can be obtained through SPSS (Statistical Product Service Solutions) data analysis: the average score of class 1 was 101.26, while the score of class 2 was 96.26. The average score of class 1 in the 2020 school year was higher than that of class 2 by 5 points, and SPSS software was used to conduct T-test and compare it with the control group. The test results showed that F=7.046, P=0.009<0.05, and the variance values were not uniform, with obvious differences. That is, after using multi-sensor technology for teaching, there were significant differences in students’ academic performance, which indicated that the education and teaching system using multi-sensor technology had a significant impact on students’ academic performance. Through the analysis of students’ test results and questionnaires, it can be seen that the teaching method using multi-sensor technology can improve students’ learning enthusiasm.