This study establishes the evaluation index system of urban garden landscape planning program on the basis of the analysis of each evaluation index of urban garden landscape planning program. Using the combination of hierarchical analysis method and entropy weighting method, the comprehensive weight value of each evaluation index is calculated, and the fuzzy comprehensive evaluation model of urban garden landscape planning program is established. And according to the comprehensive evaluation cloud model based on uncertainty, a comparison of the comprehensive cloud evaluation results of garden landscape design before and after the integration of regional culture is derived. The results of the comprehensive cloud evaluation after the integration of regional culture changed from “medium” and “good” to “good” and “excellent”, indicating that the upgrading effect of regional culture into the landscape design was good, and the overall operation effect was improved.