Under the perspective of industry-education integration, the proposal of talent cultivation model and the integration of informatized teaching resources in higher vocational innovation and entrepreneurship education have become one of the main grasps to promote the reform of higher vocational education system construction. Based on this research background, the article proposes the talent cultivation model of higher vocational innovation and entrepreneurship education based on the integration of industry and education, and integrates the informatized teaching resources by designing an unstructured teaching resources classification and integration method based on knowledge graph and matching algorithm. In the experimental part, the effect of innovation and entrepreneurship under the talent cultivation model proposed in this paper and the effect of processing informatized teaching resources by applying the method designed in this paper are analyzed. 91.5% of the teachers think that the integration of informatized teaching resources can make students understand the knowledge more intuitively and imaginatively, and 77.65% of the teachers think that the informatized teaching resources can make students more actively engaged in the whole process of learning innovation and entrepreneurship.