In order to promote the high-quality development of higher education and achieve the development goal of a strong education country, college education should pay attention to the integration and development of the content optimisation of civic and political education and practical training so as to achieve the educational goal of cultivating high-quality talents. In order to enhance the effect of content optimisation of civic and political education in colleges and universities, this paper proposes the process of content optimisation of civic and political education based on the ADDIE model and introduces the structural equation model to analyse the influence of each link on the optimisation of civic and political education content. Based on the optimised content of Civic and Political Education in the ADDIE model, a blended teaching model of Civic and Political Education in colleges and universities was established by combining BOPPPS+ blended teaching, and a teaching comparison experiment was designed to analyse its practical nurturing effect. The development link in the optimisation effect model of the content of Civic and Political Education has the most significant effect on the optimisation of the content of Civic and Political Education, and its path coefficient is 0.651. After carrying out BOPPPS+ blended teaching, the learning attitude and learning motivation of the students in the experimental class increased by 26.67% and 36.36%, respectively, and the mean score of the students’ feelings about the practical nurturing teaching effect of the Civic and Political Education course reached 6.18 points. The use of the ADDIE model to achieve the optimisation of the content of Civic and Political Education, combined with blended teaching, can enhance the effect of the practical nurturing experience of Civic and Political Education in colleges and universities and better cultivate the students’ Civic and Political literacy.