As a common and important data mining method, regression analysis plays an important role in mining useful information in data. The article explores the learning influencing factors of online Civics education in colleges and universities based on the method of multiple regression analysis. Students in a university are selected to conduct a questionnaire survey on the teaching of online Civics, and based on the results of the questionnaire survey, regression analysis and structural equation analysis are further conducted to analyze the learning influencing factors of online Civics education in colleges and universities. It is found that learning strategies have a significant positive influence on operational behavior and communication behavior, with β values of 0.234 and 0.424 respectively, which indicates that good learning strategies for cyber Civics can effectively guide, regulate and promote students’ learning communication behavior and operational behavior.