In this paper, 3D virtual technology is introduced into the design of complex clothing structure, and a 3D clothing virtual design model is constructed, and the 3D clothing pieces are spliced after constructing them in NURBS surfaces. On the basis of computational geometry technology, blending function and Adaline network are used to combine the generated free curves. Finally, extensive rendering and texture mapping are integrated with the help of OpenGL technology. The light rendering of the designed samples is performed on the Phong lighting model to optimize the visual effect of the samples. The results show that the error of 3D clothing virtual design of dressed human body is controlled between ±2.5cm. In addition, the respondents’ overall satisfaction with the design sample’s lightness, elasticity, softness, stiffness, stuffiness, dryness, wetness, and warmth during the perceptual perspective evaluation was high. The overall wearing experience of the design samples for sports comfort is good, and the comfort evaluation is high, basically meeting the user’s demands for looseness during actual exercise. It shows that the complex clothing structure design proposed in this study has stability and feasibility.