Ancient cities, as areas of urban origins, possess a deep historical heritage. However, due to the rapid urbanization process, the lack of systematic planning has caused a large number of historical and cultural heritages in ancient cities to be destroyed. In this paper, after collecting geo-architectural data of ancient buildings in historical and cultural neighborhoods using UAV inclined photogrammetry, the Wallis filter algorithm is used to pre-process the image data. In Context Capture software, the three-dimensional modeling of the ancient buildings in the historical and cultural district has been completed. Then, the evaluation indexes and methods for dynamic protection of ancient buildings in historical and cultural neighborhoods are proposed. The results show that the three-dimensional modeling technology can achieve a high degree of accuracy in terms of positional accuracy, plane, and elevation errors, meeting the accuracy indicators. After the implementation of the dynamic protection strategy of this paper, the evaluation scores of each secondary evaluation factor of the dynamic protection and reuse of ancient buildings in Yangqiao Historical and Cultural Quarter have increased to 3.19-4.98 points, all of which are at a high level. This paper is able to analyse the core content of ancient buildings to be protected through three-dimensional modelling, and take into account the protection and development of ancient buildings based on the dynamic protection strategy, which provides new theoretical ideas and practical references for the protection and continuation of the ancient buildings in the historical and cultural district.