With the development of comprehensive materials, artists’ innovation of comprehensive materials makes the works break through the original scope of easel painting, and artists give new vitality to the art works in their continuous exploration. The purpose of this study is to explore the integration of mixed-material art with the spirit and culture of the Northeast Resistance League and the path of integration and innovation of mixed-material art. In this paper, the historical background of the Northeast Antifront is studied in depth, the feasibility of art creation based on the background of the Northeast Antifront is analyzed, and the value of the spiritual culture of the Northeast Antifront is also analyzed in depth in the art creation. On this basis, regression analysis is utilized to study the art creation, viewing will and aesthetic tendency from the viewer’s point of view, which provides theoretical support for the comprehensive material art creation. Under the premise of fully considering the viewer’s willingness, the introduction of digital information technology proposes a path of integration and innovation of mixed-material art based on the historical background of the Northeast Resistance League. This study analyzes in-depth the impact of the viewing experience of comprehensive material art creation on the viewer’s willingness to revisit from the cognitive and emotional attitudes as an entry point, and the study provides new thinking and perspectives for art creation, promotes the integration of spiritual culture, technology and art, and is more of a promotion of spiritual and cultural inheritance and innovation and art research.