This paper synthesizes the theories and practices of translation and communication, and analyzes the state of translation and communication of culture in prefecture-level cities in Jiangsu Province from three main factors: the main body of translation, the way of translation, and the effect of translation, with respect to the mode of translation and communication of local culture to the outside world. The key points in the translation and dissemination of the culture of prefecture-level cities in Jiangsu Province (translation and dissemination methods, books and newspapers, and the Internet) are summarized, and the computer-aided translation technology is proposed to be improved based on the multi-featured fusion of the similarity calculation model of short texts, and a multimodal translation and dissemination strategy for the culture of prefecture-level cities in Jiangsu Province is proposed in the light of the development of multi-modal theories in the translation practice. Analyzing the performance of the improved algorithm on the computer-aided translation technology, we surveyed and counted the ways in which the respondents know about the culture of Jiangsu prefecture-level cities, and refined the ways and means of translating and disseminating the culture of Jiangsu prefecture-level cities to the outside world. Respondents are mainly informed of the culture of Jiangsu prefecture-level cities through social platforms such as WeChat and Weibo (47%) and emerging media such as news websites (21%). Taking into account the current development trend, government departments, institutional media, platform media, and self-media can be further invited to participate in the dissemination of Jiangsu prefecture-level city culture, so as to promote the better dissemination of Jiangsu prefecture-level city culture.