In order to solve the location selection for Distribution Center (here in after referred to as : D- center) is not taking into account the Logistics cost and customer service issues at the same time, a location model of D-center based on both the D-center and customer will be proposed. Taking reliability of D-centers system as a measure of customer service, we establish a multi-objective model of location D-center to minimize the Logistics cost and maximize the system reliability of D- centers . Furthermore, the paper adopts main objective method which changes multi-objective into single objective, and uses the lingo9.0 to give a solution of the model. It provides a more reasonable and comprehensive decision-making for the D-center location.