This article highlights particular mixed-mode oscillations (MMO) based on canard explosion observed in a fractional-order Fitzhugh-Nagumo (FFHN) model. In order to rigorously analyze the dynamics of the FFHN model, a recently introduced mathematical notion, the Hopf-like bifurcation (HLB), which provides a precise definition for the change between a fixed point and an S−asymptotically T−periodic solution, is used. The existence of HLB in this FFHN model is proved and the appearance of MMO based on canard explosion in the neighborhoods of such HLB points are numerically investigated using a new algorithm: the global-local canard explosion search algorithm. This MMO is constituted of various patterns of solutions with an increasing number of small-amplitude oscillations when two key parameters of the FFHN model are varied simultaneously. On the basis of such numerical experiment, it is conjectured that chaos could occur in a two-dimensional fractional-order autonomous dynamical system, with the fractional-order close to one. Therefore, this very simple two-dimensional FFHN model, presents an incredible ability to mimic the complex dynamics of neurons.