This paper studies Inventory location routing problem in supply chain distribution network planning under vendor inventory management while considering customer inventory holding cost. In order to minimize the total cost of supply chain, an optimization model is established and an improved tabu search algorithm is used to solve the problem. From the analysis, it shows that the total cost decreases as the total vehicles capacity increases, and the maximum utilization of alternative vehicles and the minimum cost of the system don’t occur at the same time in some cases.