College students are prone to psychological changes and personality distortions under heavy pressure. It will lead to catastrophe if it is not promptly guided or improperly used to reduce stress and relax. Now we integrate holistic education into the construction of the mental health education system in colleges and universities. This is conducive to solving practical problems and improving the effectiveness of system construction. We set up a differential equation model (DCE) based on the discrete choice to study mental health due to practice. At the same time, we adopt the mutual influence model of penetrating dissemination of thoughts and public opinion and human behaviour, and establish the SEIR DCE with constant input and bilinear incidence rate. The experiment verifies the algorithm’s effectiveness on the model of whole-person mental health education activities in colleges and universities.