Information technology application ability is a necessary professional ability for teachers in the information society. The means to take effective measures to promote the acquisition and transfer of teacher information technology application ability involves undertaking measures to facilitate teachers to transform teaching methods, deepen basic education curriculum reform and promote teachers’ lifelong learning. It plays a vital role in effectively promoting the independent development of majors and further cracking the bottleneck problem of educational information development. This study uses the fractional differential equation method to select 220 elementary and middle school teachers in the Northeast Teacher Education Innovation Experimental Zone as the research objects. The research objects are measured by a scale and fractional differential equations are used to build a system that includes school factors, human factors, policy and institutional factors, training factors, self-efficacy factors and motivation factors of teacher information technology application ability transfer fractional differential equation influencing factor model; we hope to solve the problem of ‘learning and use disconnect’ in the process of teacher information technology application ability training, and to promote the effective transfer of teacher information technology application ability that can be used as an important reference.