In order to study the optimization of the prefabricated concrete frame building based on the dynamic equation of the eccentric structure's horizontal-torsional coupling. First, the author analyzes the characteristics of several current representative structural forms and the problems existing in the process of industrialization. Through research on prefabricated houses at home and abroad, the key technologies involved in key processes such as design, component production, and prefabricated component installation are discussed in detail, and the problems existing in the existing technology are analyzed. Then, for a single-layer eccentric structure with soil-structure interaction, the dynamic equation is established to solve the parameters that affect the dynamic characteristics of the eccentric structural system. Finally, combined with the actual engineering, the application status of the key technologies in the construction process is analyzed, and the relevant research results are used in the project to verify the validity of the research results. The experimental results show that: Through engineering practice, we have a clearer understanding of the design and construction of prefabricated buildings, and have a deeper understanding of related technologies, and also verified the feasibility of related technologies in engineering.