For the current artwork, 3D printing design simulation technology has the disadvantage of low clarity and poor effect, which cannot effectively describe the designer's work. To this end, this paper investigates the artistic aesthetic and cultural value orientation of 3D printing. First, the 3D digitization work of the oil painting was carried out by using the multi-baseline photogrammetry method in photogrammetry technology. Then the non-measurement digital camera was checked for internal orientation elements, the control panel was photographed, and the internal orientation elements of the camera were measured using the spatial backward rendezvous solution method. Next, the digital image acquisition of the oil painting is carried out, and finally, the photos are sequentially introduced into the Lens photo multi-baseline photogrammetry system to generate the color point cloud model of the oil painting after performing the steps of homonymous point selection null-three matching and beam leveling. In order to enhance the visualization effect, the color point cloud model was used to generate a digital model of the TIN irregular triangular network to realize the 3D digitization of oil painting art. The results of the study show that the thickness of each layer obtained by UV inkjet printing of five types of inks: yellow, green, blue, black, and white is about 11.19 μm, 12.71 μm, 7.91 μm, 9.47 μm, and 13.12 μm, respectively. 3D printing technology for positive impact on art design needs to be recognized and respected, and the better development of related technologies can make the advantages and advancement of the technology itself more fully embodied.