Based on the spatial Dubin model, this paper theoretically discusses the influence of collaborative innovation on regional economic growth. The paper studies the industrial structure of enterprises by using the spatial Dubin method established by different regions and social and economic factors. It is found that collaborative innovation has a spillover effect on domestic industrial development both internally and externally. The regional migration of creative elements within the region mainly causes space overflow. And it has the characteristics of regional decline. This conclusion has specific guiding significance to the mechanism of enterprise collaborative innovation. This mode plays a positive role in promoting benign exchanges between regions and realizing industrial development and upgrading.