This paper firstly researches the generation path of innovation and entrepreneurship education ecosystem in applied undergraduate universities from the four aspects of education ecosystem, teacher team, conceptual change and system mechanism. Then, it constructs the ecological index system of innovation and entrepreneurship education and transforms the model into a parametric model by modeling the mean value parameter and dispersion parameter and approximating the smooth function of the model by using the Bayesian P-spline method. Finally, University H is taken as an example to evaluate and test the innovation and entrepreneurship education system based on the parametric model. The results show that education and teaching occupy a large proportion of the ecosystem, indicating that by actively initiating or participating in the innovation and entrepreneurship education ecology, applied undergraduate colleges and universities can rely on social capital endeavors to prompt a constant input of resources into the ecosystem, thus maintaining the benign and sustainable development of the innovation and entrepreneurship education ecosystem.