The first part of this paper examines the aesthetic and application advantages of art design using human-computer interaction technology and develops a multimodal perceptual human-computer interaction system for art design. Multimodal data is obtained using multi-scale convolutional kernels for acoustic feature extraction and deep convolutional neural networks for multiple interaction image feature fusion. Finally, a test analysis is conducted to verify the system's effectiveness in this paper. According to the results, the system has an average wake-up success rate of 99.51% and a wake-up response time of 0.3665 seconds. Implementing human-computer interaction technology and deep neural networks in art design is effective and promotes the development of art design.