The fractional microanalysis method established an optimal solution for the regional logistics distribution route. Firstly, the optimal problem of regional logistics transport routes is studied. A regional logistics information integration platform based on a fractional differential equation is constructed. The data of this platform can be used better to study the influence factors of road traffic cost. The objective and limitation of the model are obtained, and the transportation route of the system is established. The differential equation of integral order is used to solve the problem. Experiments show that the algorithm is effective and practical.