This paper firstly discusses the design method and design process of UI interface based on ergonomics, focusing on applying ergonomics principles on interactive UI interface, and discusses the design of UI interface text and color respectively. Secondly, a resilient optimization design model based on the human-computer interaction UI interface is proposed, and the constraints of the first stage and the first stage resilient sub-model are constrained using the equivalence planning method, respectively. The results show that the new version of the interactive UI interface based on ergonomics has a maximum absolute value of 26.83 for the visual coefficient and a minimum of 0.58 for the short-term memory, which is significantly more inclusive than the old version of the UI interface. This paper’s research results are expected to offer a more scientific and reliable design method for UI interface design, which will have greater practical application value and promotion prospects.