In today’s society, under the demand for high-quality talents, the professionals cultivated in colleges and universities should not only master professional skills but also need to have the spirit of innovation and entrepreneurial ability in professional aspects. In this paper, firstly, the multivariate statistical analysis method is explained, and the basic principles of the factor analysis model, principal component analysis method and systematic clustering method are given to analyze the data in the following article. Secondly, starting from the necessity of the integration of bi-initiative education and professional education of teacher training majors in colleges and universities, we constructed the 4344 specialized and innovative integrated talent cultivation model of teacher training majors and constructed an evaluation system to evaluate the effectiveness. Finally, based on the evaluation system, the data analysis of the specialized and creative integrated talent cultivation model was carried out using factor analysis, principal component analysis and systematic clustering method. The results show that in the factor analysis, the highest loading value of the first principal factor is 0.917, the contribution rate of the first principal factor is 39.67%, and the loading value of the principal component factor reaches the highest value of 0.925. The clustering analysis is based on the results of the factor analysis, and the respondents are divided into 4 clusters. The number of people in the 2nd category is more than 30 people, which accounts for about 31.41% of the total number of people. The method of multivariate statistical analysis can be used to analyze the data effectively for the specialized and integrated personnel training mode of teacher training in colleges and universities and also gives the path of specialized and integrated personnel training for teacher training.