Tourism development is one of the main means of productive cultural protection, and culture is an important factor in the attractiveness of tourist attractions. With the development of the concept of regional tourism, China’s tourism and culture have moved to a new stage. In this paper, we screen the indicators from the perspective of industrial income, the number of institutions, service teams, etc., and use the entropy weight method with relevant data to measure the level of tourism and cultural development and tourism priority. Then, the influence factors of tourism and culture development are discussed by combining the least squares regression model and geographically weighted regression model. Finally, to ensure the reliability of the conclusions, the sample reconstruction method and the supplementary variable method are used to conduct the robustness test and endogeneity test. According to the regression results, the regression coefficients for market demand and government support are positive and pass the 5% significance level test. Government support and market demand are currently the main influencing factors for the development of national tourism and culture.