Employment and entrepreneurship education in colleges and universities is an urgent need for the national implementation of the innovation-driven development strategy and the promotion of economic quality and efficiency. In this paper, the entropy weight method is used to get the original index matrix for the evaluation of the effect of the employment and entrepreneurship education model in colleges and universities, and then the data are normalized to derive the weight value of the employment and entrepreneurship education model in colleges and universities. The fuzzy evaluation of the M college employment and entrepreneurship education model is derived by using multivariate fuzzy comprehensive evaluation according to the weight value. Lastly, the fuzzy evaluation of three colleges and universities in H is done using the fuzzy comprehensive evaluation model based on entropy weight and multivariate data. The experimental results show that B2 employment and entrepreneurship hard environment, B4 financial guarantee, and B9 student achievement evaluation of M colleges are all poor. After evaluating three colleges and universities in place H, it was found that the fuzzy evaluation results of students and experts in each index were consistent. The students of the 3 colleges and universities in place H were rated by employers in the areas of adventurous spirit, willpower, and crisis management at a score of 0.5-0.6 QC, which needs to be improved. Overall employers’ satisfaction with the entrepreneurial ability of students in these 3 colleges and universities is 0.69, 0.698, and 0.709, respectively, and the employment and entrepreneurship education model of colleges and universities in place H is effective.