The outbreak of a new coronavirus pneumonia epidemic in early 2020 has had a great impact on the mental health status of college students, especially elevating the prevalence of PTSD among students. Based on the cognitive theory of ACT, this study develops a mobile networked intervention program to enhance students’ psychological state and students’ coping ability under the intervention of the ACT model and realizes the function of ACT intervention in the form of networked self-help. Through Latent Gold analysis software, the potential profiles of multiple characteristics of the subjects were categorized in order to scientifically examine the effect of the ACT model on enhancing students’ coping abilities. The results indicated that the ACT intervention group was able to significantly alleviate students’ depression levels (d = 0.71), and enhance students’ positive mental health (d = 0.42), compared to the waiting group. The results verified the effectiveness of the ACT network intervention application, which can provide a reference for the networked reform of psychological counseling in colleges and universities.