This investigation delves into the evolving patterns and regional variances in industry-academia collaboration (IAC) within Functional Nucleic Acids (FNAs) research. Analyzing publications and patents from 1990 to 2021, we dissected IAC at individual and collective levels, documenting the count and share of IAC endeavors, key partners, and regional differences. Results indicate a rising trend in IAC publications and collaborating institutions, while patent trends display a mix of increases, decreases, and steady states. The United States leads in IAC activities, correlating with its prowess in scientific research and technological innovation. Notably, regional discrepancies in IAC are mainly due to intra-regional variations, with Asia and Europe experiencing the most pronounced disparities.