Ink is the printing industry’s most basic raw material, mainly composed of resin and organic solvents. However, these organic solvents not only harm the industry’s staff but also have a great potential for environmental pollution. In recent years, with the continuous modification of resin, the structure of new products in the ink category has also changed greatly. This paper first analyzes the basic principle of polyvinyl acetate to form water-based ink, based on the synthesis method of ink, water-based ink prepared through experiments, and put forward the corresponding ink performance testing and analysis methods. Subsequently, according to the proposed test method, the prepared water-based ink was analyzed in terms of performance and water absorption. Orthogonal tests were designed to optimize the ratio of poly (vinyl acetate) copolymerization raw materials. Then, the experimental data were processed to derive the optimization formula of the process parameters for the preparation of PVAs slow-release film, and finally, the mechanism of regulating the morphology and structure of PVAs core-shell ink was obtained. The ink water resistance test showed an increase in ink surface tension from 54.154 mN/m to 60.545 mN/m due to an increase in R. The average particle size of ink particles of different core layers was around 178 nm, which was less affected by the change of core layer, and the ink particle size of different shell layers ranged from 120-290 nm and increased gradually with the increase of shell layer.