How to carry out scientific and reasonable teaching design and then improve the teaching effect is a problem faced by many college English teachers. Aiming at such problems, this paper is based on the six elements of the BOPPPS teaching model to design a blended teaching mode of university English and finally designs a blended teaching mode of university English based on the BOPPPS teaching model. In order to confirm the practicality of the teaching model, research subjects and research materials are identified, and after collecting sample data through questionnaires, the independent sample t-test algorithm is used to analyze the effect of the teaching model designed in this paper. The data show that there is a significant difference between the experimental group and the control group in the five qualities of scientific thinking, with a p-value of less than 0.05, and in terms of English achievement, the corresponding t-test result is a sig (two-sided) of 0.007<0.05, and there is a significant difference between the groups in terms of English achievement on the posttest, with a posttest mean of 92.768 for the control group and 99.774 for the experimental group. Overall, the effectiveness of the teaching model described in this paper is analyzed using the independent sample t-test algorithm. The designed online-offline hybrid teaching mode of college English based on the BOPPPS model has a more significant effect on students’ improvement in all aspects than the traditional English teaching method.