Currently, the pollution and clogging problems of injection wells in low-permeability reservoirs are becoming more and more serious, leading to a series of issues, such as the decline of fluid production in wells and the increase of pressure in injection wells. To cope with these challenges, SY organic polyacid solution was developed in this paper and its dissolution efficiency was thoroughly investigated. The experimental results show that SY organic polyacid solution has a high dissolution rate of 88.7%, which exhibits excellent scale dissolution effect, and the solvent's dissolution has a good slow-release performance to ensure the long-lasting action time. At the same time, the corrosion rate of the solvent on the N80 steel sheet is only 0.6291 g/m²-h, much lower than the industry standard, which effectively protects the safety of the construction pipeline and production column. In addition, the dissolution rate of SY organic polyacid on clay reaches 10.14% in five minutes, indicating that it prevents the ground collapse caused by excessive dissolution of clay and has good profound penetration ability. In summary, using SY organic polyacid solution can effectively solve multiple problems such as reservoir mud, inorganic scale, organic scale and water injection fouling oil, which provides an effective solution for the contamination and clogging of water injection wells in low permeability reservoirs.