The level of informatization literacy of college teachers is related to the comprehensive development of design professionals. In this paper, from the perspective of design practice teaching, we utilize the OBE model to construct a “one-core, six-double” design professional talent cultivation model. We also point out the prospects for applying the OBE model in design practice teaching. The Delphi method is used to construct the teachers’ information literacy evaluation index system. To avoid the influence of the correlation between the indexes on the evaluation results, the AHP-gray correlation combination algorithm is used to calculate the weights of the evaluation indexes. Finally, the complete evaluation index system was used to perform empirical analysis. The results show that the F-statistic of teachers’ informatization awareness and attitude (P1) is 2.349, and the P-value is 0.168, which is greater than 0.1, indicating that there is no significant difference between the scores of teachers’ informatization awareness and attitude in universities in Guangzhou and Shanghai. This study provides a foundation and reference for improving the computer literacy of design practice teaching faculty in applied colleges and universities. It aids in the advancement of design practice teaching.