The emergence of new media technology offers a significant opportunity to enhance innovation and entrepreneurship. This paper explores the underlying mechanism of this enhancement through statistical analysis. A theoretical correlation framework identifies relevant variables for the study and proposes appropriate measurement methods. A regression model, centered on partial least squares and incorporating principal component analysis, is constructed to address multicollinearity issues via residual analysis. Following the preliminary work, research samples from various regions were selected, data was collected, and input into the model, and the results were verified and discussed. The findings indicate a positive and significant correlation between “teaching practice” and innovation and entrepreneurship abilities. The regression results show that the “teaching practice” variable significantly positively affects innovation knowledge competence (β = 0.783, P < 0.05). Other dimensions also positively impact innovation knowledgeability, and the PLS model has been fully validated.