With the development of modern informatization technology, how to combine modern informatization technology with English education and teaching in colleges and universities has become a key research direction in the current education sector. This paper proposes English information literacy education and teaching based on linear regression. The research problem and object are identified based on the current situation of English education and teaching in colleges and universities, and then a research design program is developed. Using a combination of linear regression algorithms and statistical analysis software, the mechanism of the influence of modern information technology on English education and teaching is analyzed by example. The results show that the average pre-test score of students at the intermediate level is 83.854 points. In comparison, the post-test score is 89.789 points, and the post-test score is about 5.935 points higher than the pre-test score, which indicates that there is a significant improvement in the English scores of students at the intermediate level after English informatization teaching. Taking English informatization teaching as the dependent variable and “teaching equipment” and “class size” as the independent variables, the regression equation of English informatization teaching = 0.215×teaching equipment+0.144×class size. This study has a far-reaching and positive impact on improving the quality and level of university English teaching, making teaching methods richer and the teaching effect more significant.