This paper first studied the feasibility of the integration of civic education and innovation and entrepreneurship education and constructed the integration pathway of innovation and entrepreneurship education and civic education from three aspects, namely, value leadership, theoretical integration as well as practical integration. A regression analysis model was created, the parameters of the model were evaluated using least squares estimation, and the model was tested for its significance. Finally, based on the regression model, the correlation between entrepreneurship education and ideological and political education in colleges and universities was explored, and the influence of ideological and political education on the self-efficacy of college students’ innovation and entrepreneurship and their values of innovation and entrepreneurship was analyzed. The study shows that ideological and political education, classroom channel, daily education and self-efficacy are significantly positively correlated at the level of 0.05, and the correlation coefficients on students’ entrepreneurial values are 0.722, 0.673, and 0.696, respectively. This study has a reference to the healthy development of innovation and entrepreneurship education, and provides a reference to the reform of innovation and entrepreneurship education undertakings for other local colleges and universities of the same type.