The integration of Civic and Political Education and Employment Guidance can enhance the effectiveness and validity of employment guidance so that students can better solve the problems in job development and, employment, and entrepreneurship under the dual influence of employment guidance and Civic and Political Education. In analyzing the influencing factors of college students’ employability, this paper first initially identifies the relevant factors affecting college students’ employability based on survey interviews, and then applies factor analysis to explore the potential structure in the data. This study is based on doing questionnaire survey on employment influencing factors for some graduates and current students of Z university, using SPSS software to factor analyze the sample data, downgrading 10 employment influencing factors to 3 common factors, named as employment guidance factors, civic education factors, and enterprise factors, and obtaining the weights of the common factors through the normalization process. The degree of influence on college students’ employment is in descending order, with employment guidance factors, civic and political education factors, and enterprise factors being the most important factors. Employment guidance and ideological education are the key factors affecting the employment of college students, and this paper proposes relevant strategies for integrating and developing these two factors.