With the advent of the Internet + era, business English presents many new development situations and characteristics, which puts forward new and higher requirements and challenges for the cultivation of higher vocational business English composite talents. Based on the stakeholder model, this paper extracts the participating subjects of the industry-teaching integration project, and their main motivational elements. Based on the synergy model, it identifies the internal and external synergistic elements of industry-teaching integration and builds a model of internal and external synergistic mechanisms, which lays a theoretical foundation for the subsequent proposal of innovative paths of business English talent cultivation in higher vocational colleges. From 64 policies on industry-teaching integration in higher vocational colleges, synergistic elements of industry-teaching integration talent cultivation are identified, and the fuzzy set qualitative comparative analysis method is used to explore the combination of synergistic elements that can improve the effectiveness of industry-teaching integration talent cultivation projects, i.e., the new path of business English talent cultivation. The study found that enterprise size, discipline type, project motivation, project action, and project constraints are five conditional variables of the industry-teaching integration project. The necessity analysis of individual condition variables found that the consistency and coverage of the five variables did not exceed 0.8 at the same time, indicating that none of the five condition variables could be a necessary condition. Under the condition that the 5 conditional variables are combined, 5 innovative paths of collaborative industry-education cultivation of business English talents are obtained, and the coverage and consistency values of the paths are 0.808042 and 0.913024, both exceeding 0.8, which are able to explain adequately the high performance of collaborative talent cultivation in higher vocational colleges and universities.