This paper combines the teaching of a 3D animation course with the blended teaching mode and constructs a framework for the design of 3D animation blended teaching reform. Based on the fuzzy comprehensive evaluation algorithm, we adopt qualitative and quantitative methods to determine the evaluation index system of teaching reform, divide the course teaching objectives, teaching content, learning resources, online learning and teaching design and classroom organization into five first-level indexes, establish the weights of the evaluation index system, and complete the construction of the fuzzy comprehensive evaluation system of 3D animation blended teaching. Examine the design and teaching effects of 3D animation that blends learning from different dimensions, and examine the correlation between learners’ multidimensional recognition of teaching reform and its learning impact. By combining the weights of each index, the fuzzy comprehensive evaluation results are obtained by determining the affiliation degree of each index using the fuzzy statistical method. The operation results show that the fuzzy comprehensive evaluation scores of the five first-level indicators of teaching reform are 0.754546, 0.69943, 0.638926, 0.66888, and 0.5966. It can be seen that the comprehensive evaluation results of the five aspects have achieved good results. The evaluation of teaching reform’s effects can be targeted and feasible using a fuzzy comprehensive evaluation model.