Based on geographic and location advantages, in order to efficiently pool limited resources and improve the quality of talent cultivation, universities in Zhuhai and Macao should break the inter-university and cross-border barriers and innovatively explore a path of collaborative cultivation and development of internationalized talents. The path is based on the theory of synergy, with the industry-education synergy system dynamics model as the analytical framework. Faced with the key development industries and sectors in the Greater Bay Area, it relies on the industry-education alliance built by the government, schools, enterprises, and the talent market. It aims to cultivate a batch of composite talents with management and production skills who are urgently needed in the field, multi-functional, with internationalized vision, and with multi-language service ability so as to better serve the regional economic development. Focusing on the synergy of talent cultivation goals, talent cultivation process, talent cultivation results, and human resources supporting synergy, we strive to create a good ecology of Zhuhai-Macao internationalized talent cultivation from fragmented and disordered to globally organized and from individualism to synergistic cultivation.