Under the guidance of foreign language curriculum design theory, foreign language courses in colleges and universities should construct a foreign language course teaching system from the aspects of reconfiguring the course objectives, updating the course content, and designing a diversified evaluation system. This paper combines the 5Ds framework with the GFKE model to establish the teaching system of foreign language courses in colleges and universities, designs the blended teaching mode of foreign language courses in colleges and universities, and constructs the corresponding course evaluation index system. Taking Z University in H province as the research object, the relevant teaching process of foreign language courses was designed, the coefficient of variation method solved the weights of evaluation indexes, and the teaching effect of foreign language courses in universities was comprehensively evaluated by set-pair analysis. On this basis, a validation analysis was carried out using the dimensions of teaching effect and teaching evaluation. The reading scores of students in the Experiment 1 class went up by 3.31 points, and the average score of students’ writing test scores went up by 53.86%, as per the findings. In the posttest of the depth of knowledge of English vocabulary, the experimental 1 class scored 25.83 points, which was 45.28% more than the control 2 class’s score. Blending foreign language courses based on the GRKE model can promote the improvement of students’ foreign language learning ability, and teaching evaluation results will be more accurate.