In this paper, web crawler technology is used to obtain research data on news dissemination of self media and mainstream media, data cleaning is performed on the initial data through Pandas package, and the processed research data is stored in the database. From the acquired research data of self media and mainstream media news dissemination, the independent variables and dependent variables are determined to complete the construction of linear regression model of mainstream media news dissemination, and the influence of self media on mainstream media news dissemination is judged by calculating the correlation coefficients of the linear regression model. The results show that compared with X1, X3 (Bate=0.223, p<0.01) and X7 (Bate=−0.016, p<0.01), have a significant positive effect on the overall communication effect of mainstream media, indicating that the comprehensive population coverage and communication speed of self media undoubtedly bring considerable influence on the news dissemination of mainstream media. This study hopes to provide theoretical support for the research of related workers. It significantly promotes the joint development of self media and mainstream media news dissemination.