This paper selects research variables and compares and analyzes the different performances, influence effects and realization paths of industrial intelligence and economic high-quality development in the East, Central and West regions and within the regions. The panel data regression model is used to study the role and path of the manufacturing industry’s upgrading by intelligent technology. The results show that industrial intelligence has a significant positive effect on the high-quality development of the economy in the eastern, central and western regions (P<0.01). In the east (0.198), there is a stronger promotion effect than in the center (0.168), and the weakest effect is in the west (0.142). Intelligent technology can promote the upgrading of the manufacturing industry chain structure by clarifying market demand, improving human capital levels, and optimizing factor allocation.