Epstein-Barr Virus (EBV) belongs to the Herpesviridae family is a DNA virus that widely seen all the world and it can be transmitted through close contact, oropharyngeal secretions, blood and contaminated belongings. EBV infections generally emerge in childhood and remains asymptomatic. Epstein Barr Nuclear Antigens (EBNA), Viral capsid antigen (VCA) and Latent Membrane Protein (LMP) are strong a virus that can infect host cells and remain latent during infection. If EBV is latent in the host under natural conditions, it can affect the cell and cause severe diseases such as Infectious Mononucleosis (IM), Burkitt's lymphoma (BL). BL is undoubtedly the most risk and serious disease cause of EBV. BL is especially an emerge as the translocation genes of MYC a results immunoglobulin chains.