In this study, we aimed to investigate polymorphic structures in some gene loci which are risk for osteoporosis. The genes we chose are genes that encode the proteins necessary for bone health. These proteins are collagen type 1, estrogen receptor, vitamin D receptor, lactase, osteoprotegerin and interleukin 6. Polymorphic structure analysis was performed at eight different points of the genes encoding these six molecules. The whole blood samples to be analyzed were taken from the patients who applied to the Physical Therapy and Rehabilitation Clinic of Atatürk University. Bone Mineral Density is the basic criterion we use in patient selection. Polymorphic Structure Analysis was done at Atatürk University, Department of Biochemistry, and Department of Molecular Laboratory. Genomic DNA was isolated from whole blood samples by the manual method. DNA quantity analysis was performed with UV spectrophotometer. Primers specific gene sequences were amplified and labeled in Multiplex PCR. The samples obtained after the PCR applications were subjected to Agarose Gel Electrophoresis. DNA sequence amplifications were identified in the Array Tuple by specific allele hybridization. Patient genotype results were obtained from Solas 1 Reader with an Array Tube reader system. A total of 1200 results were obtained from whole blood samples taken from 150 volunteers. It was observed that there was a correlation between increasing number of polymorphic structures and decreasing bone densities. The risk ratios of osteoporosis of polymorphic structures were determined. The polymorphic structures in the analyzed genes pose a risk for osteoporosis. It was concluded that osteoporosis has a strong genetic component but should be evaluated together with other non-genetic factors.