Purpose: The purpose of this research is to examine protective effects of Alliin on cecal ligation and puncture (CLP)-induced lung injury. Material and Method: In our experiment, the rats were separated as 4 groups including sham control, CLP, CLP + Alliin 100 mg/kg and CLP + Alliin 200 mg/kg. Some oxidant, antioxidant and inflammatory parameters were evaluated in lung tissues obtained at the end of the experiment. Findings: In current study, we observed that the oxidant and inflammatory parameters increased and antioxidant parameters decreased in the CLP group but the antioxidant parameters increased and oxidant parameters decreased in treatment groups suggesting that administration of Alliin is protective against CLP- induced lung oxidative damage.